Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system
نویسندگان
چکیده
منابع مشابه
Stimuli Sensitive Hydrogels in Drug Delivery Systems
Hydrogels are the 3 dimensional cross linked polymeric networks which absorb the water 10-20 times of its molecular weight. Hydrogels are sensitive to different environmental stimuli like pH, temperature, ion, electric signals, light, pressure, antigen specific, enzyme sensitive, and glucose levels. When the environment is get change they get swell, and swelling is the most important characteri...
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The aim of this review is to explore the advanced progress of ophthalmic products; drug delivery is one of the mainly tricky and complicated fields for researchers. The conventional formulations such as solutions, suspensions, ointments, etc. shows some constraint in increase of pre-corneal elimination, elevated changeability in efficiency, blurred vision and also diminish their bioavailability...
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Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can...
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Treating various ailments of eye utilizes mostly two strategies i.e. delivery of the therapeutic agent by development of a novel delivery system or by enhancing the permeation of therapeutically active agent by the use of penetration enhancers or by the alteration of its physicochemical properties. Conventional ophthalmic drugs delivery system including eye drops, ointments and gels, are no lon...
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Promising management of eye ailments take off effective concentration of drug at the eye for sufficient period of time. Ocular drug delivery is hampered by the barriers protecting the eye. The bioavailability of the active drug substance is often the major hurdle to overcome. Conventional ocular dosage form, including eye drops, are no longer sufficient to combat ocular diseases. This article r...
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ژورنال
عنوان ژورنال: Indian Journal of Ophthalmology
سال: 2010
ISSN: 0301-4738
DOI: 10.4103/0301-4738.71677